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secretase

Synonyms

Noun

1. enzyme

Usage
Charting γ-secretase substrates by explainable AI - Nature
Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity - Journal of Neuroscience
Glycemic variability associated with gamma secretase inhibitor therapy in a type 1 diabetic patient undergoing treatment for desmoid tumor: a case report - Frontiers
Phase 2 GABriella Study Represents First Step in Testing Selective Novel Y-Secretase Modulators for Prodromal Alzheimer Disease - Neurology Live
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease - Nature
Explainable AI helps decode the substrate specificity of γ-secretase enzyme - News-Medical
Zolucatetide Receives Orphan Drug Designation for Desmoid Tumors - CancerNetwork
Molecular mechanism of substrate recognition and cleavage by human γ-secretase - Science | AAAS
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 - PNAS
Another BACE inhibitor fails in phase III trials - Clinical Trials Arena
Therapeutic effects of a novel synthetic α-secretase - Frontiers
Recognition of the amyloid precursor protein by human γ-secretase - Science | AAAS
Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform - Nature
Secretase promotes AD progression: simultaneously cleave Notch and APP - Frontiers
Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons - Journal of Neuroscience
Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease - Frontiers
Defining the minimum substrate and charge recognition model of gamma-secretase - Nature
A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase - Nature
Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein | Communications Biology - Nature
Complex Regulation of gamma-Secretase: from Obligatory to Modulatory Subunits - Frontiers
Structural basis of Notch recognition by human γ-secretase - Nature
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease - Nature
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease - Nature
Structural basis of human γ-secretase inhibition by anticancer clinical compounds - Nature
Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state - PNAS
SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy - Nature
EBP1 potentiates amyloid β pathology by regulating γ-secretase - Nature
An atomic structure of human γ-secretase - Nature
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator - PNAS
γ-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation - Nature
Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation - PNAS
Molecular pathogenesis of desmoid tumor and the role of γ-secretase inhibition - Nature
Gamma-secretase-dependent signaling of receptor tyrosine kinases - Oncogene - Nature
Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex - Nature
Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling - Nature
Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate - PNAS
Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-β Accumulation in Alzheimer’s Disease - Science Partner Journals
APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding - Nature
A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss - Nature
γ-secretase directly sheds the survival receptor BCMA from plasma cells - Nature
Three-dimensional structure of human γ-secretase - Nature
Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis - Nature
γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) - The Lancet
1999: Identifying the key enzyme β-secretase - Nature
A promising new γ-secretase modulator for Alzheimer’s disease - Rockefeller University Press
η-Secretase processing of APP inhibits neuronal activity in the hippocampus - Nature
SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions - Science | AAAS
A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease - The New England Journal of Medicine
Noninvasive Assessment of β-Secretase Activity Through Click Chemistry-Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease - Wiley
Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms - Frontiers
Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio - Nature
Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease - PNAS
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease - Nature
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase - Nature
Efficient production of a mature and functional gamma secretase protease - Nature
γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors - Frontiers
Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum - Rockefeller University Press
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production - Nature
Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarks | Scientific Reports - Nature
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities - Science | AAAS
GSAP modulates γ-secretase specificity by inducing conformational change in PS1 - PNAS
Differential Effects between γ-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice - Journal of Neuroscience
Aβ-Generating Enzymes : Recent Advances in β- and γ-Secretase Research - ScienceDirect.com
Inhibition of amyloid precursor protein processing by β-secretase through site-directed antibodies - PNAS
AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling - Nature
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease - Nature
BACE1 is the major β-secretase for generation of Aβ peptides by neurons - Nature
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo - PNAS
Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site - Nature
γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1 - Science | AAAS
Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase - Frontiers
Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence - Nature
The beta secretase BACE1 regulates the expression of insulin receptor in the liver - Nature
Modulation of γ-secretase specificity using small molecule allosteric inhibitors - PNAS
A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis | Cell Research - Nature
Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion | Molecular Psychiatry - Nature
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease - Nature
Royal jelly peptides: potential inhibitors of β-secretase in N2a/APP695swe cells - Nature
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation - Nature
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 - PNAS
Sex-Specific Regulation of β-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease - Journal of Neuroscience
A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma - Nature
DNA damage-inducing agents elicit γ -secretase activation mediated by oxidative stress - Nature
Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures - The New England Journal of Medicine
Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase - Nature
Targeting the β secretase BACE1 for Alzheimer's disease therapy - The Lancet
β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease - Frontiers
TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies - Nature
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors - Nature
γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment - Journal of Neuroscience
An Accomplice for γ-Secretase Brought into Focus - Science | AAAS
γ-Secretase and Human Disease - Science | AAAS
Microbial infection promotes amyloid pathology in a mouse model of Alzheimer’s disease via modulating γ-secretase - Nature
Influence of apolipoprotein E (apoE) on ADAM10 secretase in cerebrospinal fluid of older adults with Alzheimer’s disease - Wiley
γ-Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin - Journal of Neuroscience
The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner - Nature
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients - PNAS
γ-Secretase: proteasome of the membrane? - Nature
Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10 - Nature
Structural basis of human γ-secretase assembly - PNAS
Foreign Language Equivalents
Foreign Language Equivalents of 'secretase'
Language Equivalent   Language Equivalent
French    Spanish
Misspellings - Typos
secretse,   sceretase,   secrettase,   secretaase,   seceetase,   srcretase,   seretase,   secrretase,   sevretase,   secretae,   secreetase,   secrwtase,   secretaae,   secrtease,   ssecretase,   aecretase,   swcretase,   secretsse,   secrtase,   escretase,   secretade,   sexretase,   secretasse,   secretas,   secetase,   seecretase,   secertase,   decretase,   secrease,   secreyase,   secretasr,   sectetase,   secretaes,   secrrtase,   seccretase,   secretasee,   secrerase,   sercetase,   secretasw,   scretase,   secretsae,   ecretase,   secreatse
Words Starting with Letter - 'A'
a a battery a billion
a bit a bit much a capella singing
a cappella singing a couple of a few
a fortiori a good deal a great deal
a horizon a hundred a hundred and one
a hundred thousand a hundred times a kempis
a la carte a la mode a level
a little a lot a million
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